- Sep 20, 2017 -
Proper use of donepezil hydrochloride tablets
Alzheimer's disease is a chronic neurodegenerative disease, characterized by progressive cognitive decline, mental behavior symptoms and daily self-care ability decline. Clinically, cholinesterase inhibitors often used in the disease, donepezil hydrochloride for the current commonly used drugs, then, you know how to use this medicine, should pay attention to what?
The initial dosage of donepezil hydrochloride is 5mg (1 tablet) once a day, before going to bed, and at least the initial dose is maintained for more than one month to increase the dosage to 10mg (2 tablets) Once a day. The maximum recommended dose of daily 10mg, due to greater than the daily dose of 10mg has not been a clinical study, therefore, the daily dose should not exceed 10mg, to prevent excessive dose caused by adverse reactions; stop treatment, the efficacy of donepezil hydrochloride gradually diminished , Discontinuation of treatment without rebound phenomenon; for renal insufficiency and mild to moderate liver dysfunction, the elimination of donepezil hydrochloride is not affected, therefore, these patients do not need to adjust the dose.
Application of this drug should pay attention to: 1. Anesthesia, can enhance the succinylcholine type of drug muscle relaxation. 2. Donepezil hydrochloride because of its pharmacological effects can produce vagal neurovascular heart effects, suffering from sick sinus syndrome or other patients with supraventricular heart disease should be used with caution. 3. Because of its role in choline, asthma history or history of obstructive pulmonary disease patients should be used with caution. 4. Cholesteryl esterase inhibitors may increase the secretion of gastric acid, therefore, for ulcer history or taking non-steroidal anti-inflammatory drugs in patients should pay close attention to possible gastric bleeding.
In addition, although almost no reports of liver function degradation of donepezine, including hepatitis, but if there is unexplained degradation of liver function, should be considered to disable; because the drug includes illusion, irritability and aggressive behavior of the mental disorder report Need to reduce or stop treatment.