Hydrocortisone CAS NO 50-23-7

Hydrocortisone CAS NO 50-23-7

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Product Details

Basic information Hydrocortisone CAS NO 50-23-7

Product Name: Hydrocortisone
Molecular Formula : C21H30O5
Molecular Weight: 362.46

CAS No.: 50-23-7

Appearance: White crystalline powder

Specifications:

EP6/USP37;EP8

Usages :

Treat for allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, etc.

Adrenocortical insufficiency and hypopituitarism

Items

Specifications

Results

Appearance (Ph. Eur.)

A white or almost white, crystalline powder

White crystalline powder

Solubility (Ph. Eur.) (annual )

Practically insoluble in water, sparingly soluble in acetone and in alcohol, slightly in methylene chloride

Complies

Identification



A: IR-spectrum (Ph. Eur.)

Meets the requirement

Complies

B: TLC (Ph. Eur.)

Meets the requirement

Complies

A: IR-spectrum (USP)

Meets the requirement

Complies

B: UV Absorption (USP)

Meets the requirement

Complies

Specific optical rotation



(Ph. Eur.)

Between +150°and 156°

+153.8°

(USP)

Between +150°and 156°

+154.0°

Loss on drying



(Ph. Eur.)

Not more than 1.0%

0.07%

(USP)

Not more than 1.0%

0.07%

Residue on ignition (USP)

Not more than 0.5%

0.10%

Related substances (Ph. Eur.)



Any individual impurity

Not more than 0.5%

0.25%

Sum of impurities

Not more than 1.5%

1.17%

Chromatographic purity (USP)



Any individual impurity

Not more than 0.5%

0.30%

Sum of impurities

Not more than 2.0%

1.22%

Assay



UV Absorption (Ph. Eur.)

Between 97.0% and 103.0%

100.0%

HPLC (USP)

Between 97.0% and 102.0%

99.8%

Residual solvent (In-house)



Methanol

Not more than 500ppm

Not detected out

Ethanol

Not more than 2000ppm

541ppm

Methylene chloride

Not more than 600ppm

Not detected out

Chloroform

Not more than 60ppm

Not detected out

Particle size (In-house)

90% not more than 15microns

Complies

Conclusion

The product conforms to Ph.Eur.6/USP37


Items

Specifications

Results

Appearance

A white or almost white, crystalline powder

White crystalline powder

Solubility

Practically insoluble in water, sparingly soluble in acetone and in alcohol, slightly in methylene chloride

Complies

Identification



A: IR-Spectrum

Meets the requirement

Complies

B: HPLC

Meets the requirement

Complies

Specific optical rotation

Between+162°and +168°

+165.4°

Loss on drying

Not more than 1.0%

0.09%

Related substances



Impurity D RRT0.2

Not more than 0.50%

0.23%

Impurity H RRT0.3

Not more than 0.15%

N.D

Impurity I RRT0.5

Not more than 0.50%

0.17%

Impurity M RRT0.7

Not more than 0.10%

0.09%

Impurity G RRT0.8

Not more than 0.40%

0.08%

Impurity E RRT0.86

Not more than 0.50%

0.09%

Impurity A RRT0.96

Not more than 0.20%

0.09%

Impurity B RRT1.1

Not more than 0.20%

N. D

Impurity F RRT1.4

Not more than 0.30%

0.06%

Impurity C RRT1.5

Not more than 0.50%

0.08%

Impurity N RRT1.7

Not more than 0.15%

N.D

Any unspecified impurity

Not more than 0.10%

Complies

Sum of impurities

Not more than 2.0%

1.01%

Assay

Between 97.0% and 103.0%

100.7%

Residual solvents (in-house)



Methanol

Not more than 500ppm

Not detect out

Ethanol

Not more than 2000ppm

Not detect out

Methylene chloride

Not more than 600ppm

Not detect out

Chloroform

Not more than 60ppm

Not detect out

Particle size (In-house )

90% not more than 15micron

Complies

Conclusion

The product conforms to Ph.Eur. 8.0


Contacts:

Ms. Lvky Lv

Email: lv@china-sinoway.com

Tel: 0086-0592-5887165

Mob/WhatsApp/Wechat: 0086-18350268056

Skype: lvyundan33



Specializing in the research, development and custom manufacturing of hydrocortisone cas no 50-23-7, SINOWAY, though situated in China, enjoys good reputation among international customers. We supply you with pure natural and well extracted products which can give the best care.

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