Lamivudine CAS: 134678-17-4

Lamivudine CAS: 134678-17-4

Product Name: Lamivudine Synonyms: 4-AMINO-1-((2R,5S)-2-HYDROXYMETHYL-[1,3]OXATHIOLAN-5-YL)-1H-PYRIMIDIN-2-ONE CAS: 134678-17-4 Molecular Formula: C8H11N3O3S Molecular Weight: 229.25 USP Specification: Use: Anti-Aids API Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor...

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Product Details

Product Name: Lamivudine
Synonyms:  
4-AMINO-1-((2R,5S)-2-HYDROXYMETHYL-[1,3]OXATHIOLAN-5-YL)-1H-PYRIMIDIN-2-ONE

CAS: 134678-17-4

Molecular Formula: C8H11N3O3S
Molecular Weight:  229.25 
 USP

 Specification:

ASSAY ITEMS

SPECIFICATIONUSP

Appearance

White to off-white crystalline powder

Solubility

Soluble in water, sparingly soluble in ethanol,   practically insoluble in ethyl acetate

Light Absorption

Not more than 0.0015 (440nm, 100px cell, 50mg/ml)

Identification

A) The IR Spectrum of test sample corresponds to the   standard IR spectrum of Lamivudine

B) The retention   time of the major peak in the chromatogram of the test solution corresponds   to that in chromatogram of the reference solution, as obtained in the test of   Limit of Lamivudine enantiomer.

Water

Not more than 0.2%

Limit of   Lamivudine Enantiomer

Not more than 0.3%

Residual Solvents

Ethanol is not more than 0.2%

Triethylamine   (TEA) is not more than 0.1%

Dichloromethane is   not more than 0.06%

Toluene is not   more than 0.089%

N,N-Dimethylformamide   is not more than 0.088%

n-Hexane is not   more than 0.029%

Total residual   solvents not more than 0.3%

Chromatographic   Purity

Salicylic acid is not more than 0.10%

Relative retention   time at about 0.4 impurity is not more than 0.3%

Relative retention   time at about 0.9 impurity is not more than 0.2%

Any other   individual impurity is not more than 0.1%

Total impurities

not more than 0.6%

HPLC Assay   (Anhydrous basis)

Not less than   98.0% and not more than 102.0%

 

Use: Anti-Aids API

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir and Epivir-HBV. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.


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Specializing in the research, development and custom manufacturing of lamivudine cas:134678-17-4, SINOWAY, though situated in China, enjoys good reputation among international customers. We supply you with pure natural and well extracted products which can give the best care.

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