Imatinib Mesylate CAS NO:220127-57-1

Imatinib Mesylate CAS NO:220127-57-1

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Product Details

Basic information of Imatinib Mesylate CAS NO:220127-57-1

Name

Imatinib Mesylate

Alias

GLIVEC;GLEEVEC;IMATINIB METHANESULFONATE; CGP-57148B; 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-phenyl]-benzamide Mesylate;

CAS NO.

220127-57-1

Molecular Formula

C30H35N7O4S

Molecular Weight

589.71

QualityStandard

In-house Standard

Package Size

Aluminium bag; 50g/bag; 100g/bag

Brief Introduction

Imatinib mesylate (also called Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia.
As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans.

Storage condition

Preserve in tight, light-resistant containers, and store at 15℃ —30℃ .

Use of Imatinib Mesylate:

A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL)

echinocandin antifungal, active against infections with Aspergillus and Candida, inhibits cell wall synthesis

Anticancer

COA ofImatinib Mesylate:

TEST ITEM

SPECIFICATION

RESULTS

Appearance

White or slightly yellow crystalline powder, homogeneous and with fine grain size. No foreign particles are observed.

Slightly yellow crystalline Powder

Solubility

Soluble in water and in acids solutions,slightly soluble in methanol insoluble in acetone, acetonitrile and dilute hydroxyl alkaline solution

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Identification

Complies

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Water

≤1.0%

0.8%

Heavy metals

≤20ppm

10ppm

Melting range

212– 220 ℃

214-216℃

Residue on ignition

≤0.1%

0.08%

Particle size

90% < 100 μm

50% < 50 μm

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Bulk density

NLT 0.4g/ml

0.6g/ml

Chromatographic

purity

Individual impurities: ≤0.2%

Total impurities: ≤0.5%

0.16%

0.32%

Assay

98.5%-102.0% of Imatinib mesylate,

calculated on anhydrous basis.

99.70%



Residual solvents

Ethyl acetate: ≤5000ppm

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Acetone: ≤5000ppm

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N,N-Dimethylformamide: ≤880ppm

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Methanol: ≤3000ppm

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Dichloromethane: ≤300ppm

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For more details, pls. contact with me .

Ms. Denise Lai
International Trade Dept.
Sinoway Industrial Co.,Ltd 
(established in 1987, ISO9001:2008 and SGS certificated)
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Tel:0086 592 5887167
Fax:0086 592 5854960
Skype: sinoway-dl
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Specializing in the research, development and custom manufacturing of imatinib mesylate cas no:220127-57-1, SINOWAY, though situated in China, enjoys good reputation among international customers. We supply you with pure natural and well extracted products which can give the best care.

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